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    Catégorie de document Article paru dans une revue
    Titre Multisensory VR interaction for Protein-Docking in the CoRSAIRe project
    Auteur principal Nicolas Férey
    Co-auteurs Julien Nelson, Christine Martin, Lorenzo Picinali, Guillaume Bouyer, Alex Tek, Patrick Bourdot
    Paru dans Virtual Reality (special issue on Virtual Reality Applications 2009
    Comité de lecture Oui
    Copyright Springer London
    Année 2009
    Statut éditorial Accepté - publication en cours

    Proteins take on their function in the cell by interacting with other proteins or biomolecular complexes. To study this process, computational methods, collectivelly named protein docking, are used to predict the position and orientation of a protein ligand when it is bound to a protein receptor or enzyme, taking into account chemical or physical criteria. This process is intensively studied to discover new protein biological functions for proteins and to better understand how these macromolecules take on these functions at the molecular scale. Pharmaceutical research also employs docking techniques for a variety of purposes, most notably in the virtual screening of large databases of available chemicals to select likely molecular candidates for drug design. The basic hypothesis of our work is that Virtual Reality and multimodal interaction can increase efficiency in reaching and analysing docking solutions, in addition to fully a computational docking approach. To this end, we conducted an ergonomic analysis of the protein-protein current docking task as it is carried out today. Using these results, we designed an immersive and multimodal application where Virtual Reality devices, such as the 3D mouse and haptic devices, are used to interactively manipulate two proteins to explore possible docking solutions. During this exploration, visual, audio and haptic feedbacks are combined to render and evaluate chemical or physical properties of the current docking configuration.

    Mots-clés Protein Docking / User-Centered Design / Virtual Reality / Multimodal Rendering
    Equipe Espaces acoustiques et cognitifs
    Cote Ferey09a

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